Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC053
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-09 09:14
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT Madopar 4x1/2 Madopar HBS 1 x1 difficulites with ELEL

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 30 individuals with a value less than 0.63 were subsequently diagnosed with PD. That is, 71.43% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.63 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 38, 'TN': 27, 'TP': 4, 'FP': 3}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 25, 'TN': 20, 'TP': 17, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 9, 'TN': 6, 'TP': 33, 'FP': 24}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 26.788
timePerCircleCoV 0.172396
timePerCircleSlope -0.0494206
meanError 1.19501
tremorFreq 6.73828
tremorRelPower 35.3663
tremorGyroAmpMean 0.0252606
tremorGyroAmpSlope 0.00117661
tremorGyroAmpCoV 0.411317
tremorCoordAmpMean 0.0386089
tremorCoordAmpSlope 0.000789666
tremorCoordAmpCoV 0.351478
tremorAccAmpMean 0.0342824
tremorAccAmpSlope -0.000264775
tremorAccAmpCoV 0.384983
tremorPcRelVar 0.765492
tremorPcX 0.932053
tremorPcY 0.362323

Circle Segment 1

Duration 33.76 s, Accuracy Estimate 1.121 (lower is better)

Circle Segment 2

Duration 34.8 s, Accuracy Estimate 0.938 (lower is better)

Circle Segment 3

Duration 25.6 s, Accuracy Estimate 0.839 (lower is better)

Circle Segment 4

Duration 27.28 s, Accuracy Estimate 1.024 (lower is better)

Circle Segment 5

Duration 29.6 s, Accuracy Estimate 1.114 (lower is better)

Circle Segment 6

Duration 25.36 s, Accuracy Estimate 1.106 (lower is better)

Circle Segment 7

Duration 22.64 s, Accuracy Estimate 1.161 (lower is better)

Circle Segment 8

Duration 24.36 s, Accuracy Estimate 1.135 (lower is better)

Circle Segment 9

Duration 23.48 s, Accuracy Estimate 1.229 (lower is better)

Circle Segment 10

Duration 21.0 s, Accuracy Estimate 2.284 (lower is better)

Spiral

numSpirals 2
timePerSpiralMean 92.2
timePerSpiralCoV 0.0165656
timePerSpiralSlope 0.0234273
meanError 1.68056
tremorFreq 6.34766
tremorRelPower 32.7077
tremorGyroAmpMean 0.0187357
tremorGyroAmpSlope -1.13666e-05
tremorGyroAmpCoV 0.362075
tremorCoordAmpMean 0.0460991
tremorCoordAmpSlope -0.00103146
tremorCoordAmpCoV 1.37327
tremorAccAmpMean 0.0525635
tremorAccAmpSlope 0.000313954
tremorAccAmpCoV 0.136236
tremorPcRelVar 0.831976
tremorPcX 0.0711876
tremorPcY -0.997463

Spiral Segment 1

Duration 91.12 s, Accuracy Estimate 1.638 (lower is better)

Spiral Segment 2

Duration 93.28 s, Accuracy Estimate 1.723 (lower is better)

Elel

eDurationMean 0.705882
eDurationStd 0.149552
eDurationStdnorm 0.211866
eDurationMedian 0.6725
eDurationQuartdelta 0.165
eDurationQuartdeltanorm 0.245353
eDurationKurt 3.32785
eDurationTrenddiff -0.135
eDurationTrendratio 0.82
eWidthMean 4.40815
eWidthStd 1.27737
eWidthStdnorm 0.289774
eWidthMedian 4.446
eWidthQuartdelta 1.755
eWidthQuartdeltanorm 0.394737
eWidthKurt 4.1516
eWidthTrenddiff 0.117
eWidthTrendratio 1.02632
eHeightMean 8.35862
eHeightStd 1.81786
eHeightStdnorm 0.217483
eHeightMedian 8.2485
eHeightQuartdelta 2.925
eHeightQuartdeltanorm 0.35461
eHeightKurt 2.23992
eHeightTrenddiff 0.702
eHeightTrendratio 1.09091
eAspectMean 0.536579
eAspectStd 0.139251
eAspectStdnorm 0.259516
eAspectMedian 0.512195
eAspectQuartdelta 0.216552
eAspectQuartdeltanorm 0.422791
eAspectKurt 2.5705
eAspectTrenddiff 0.0668768
eAspectTrendratio 1.13871
eSlantMean -0.384438
eSlantStd 0.294332
eSlantStdnorm -0.765616
eSlantMedian -0.336456
eSlantQuartdelta 0.392416
eSlantQuartdeltanorm -1.16632
eSlantKurt 2.28684
eSlantTrenddiff -0.166667
eRtopMean 0.408072
eRtopStd 0.238284
eRtopStdnorm 0.583926
eRtopMedian 0.408508
eRtopQuartdelta 0.284884
eRtopQuartdeltanorm 0.697376
eRtopKurt 2.56213
eRtopTrenddiff -0.225
eRbotMean 1.14376
eRbotStd 0.393803
eRbotStdnorm 0.344307
eRbotMedian 1.10243
eRbotQuartdelta 0.530812
eRbotQuartdeltanorm 0.481493
eRbotKurt 2.35825
eRbotTrenddiff 0.345455
eRrightMean 0.6378
eRrightStd 0.267726
eRrightStdnorm 0.419765
eRrightMedian 0.663394
eRrightQuartdelta 0.269048
eRrightQuartdeltanorm 0.405562
eRrightKurt 9.40124
eRrightTrenddiff -0.126717
eRleftMean 0.597712
eRleftStd 0.180545
eRleftStdnorm 0.302061
eRleftMedian 0.57888
eRleftQuartdelta 0.282385
eRleftQuartdeltanorm 0.487813
eRleftKurt 2.49804
eRleftTrenddiff 0.133333
lDurationMean 0.968788
lDurationStd 0.194639
lDurationStdnorm 0.20091
lDurationMedian 0.93
lDurationQuartdelta 0.24125
lDurationQuartdeltanorm 0.259409
lDurationKurt 3.38555
lDurationTrenddiff -0.2425
lDurationTrendratio 0.778539
lWidthMean 6.64418
lWidthStd 1.66282
lWidthStdnorm 0.250267
lWidthMedian 6.084
lWidthQuartdelta 2.42775
lWidthQuartdeltanorm 0.399038
lWidthKurt 1.92005
lWidthTrenddiff 1.404
lWidthTrendratio 1.23301
lHeightMean 21.7904
lHeightStd 3.16631
lHeightStdnorm 0.145308
lHeightMedian 21.879
lHeightQuartdelta 4.94325
lHeightQuartdeltanorm 0.225936
lHeightKurt 2.46269
lHeightTrenddiff 2.691
lHeightTrendratio 1.13143
lAspectMean 0.311629
lAspectStd 0.0921831
lAspectStdnorm 0.29581
lAspectMedian 0.309091
lAspectQuartdelta 0.150611
lAspectQuartdeltanorm 0.487272
lAspectKurt 2.94372
lAspectTrenddiff 0.0147516
lAspectTrendratio 1.04849
lSlantMean -0.23086
lSlantStd 0.195956
lSlantStdnorm -0.848811
lSlantMedian -0.19697
lSlantQuartdelta 0.23653
lSlantQuartdeltanorm -1.20085
lSlantKurt 3.13622
lSlantTrenddiff 0.0235274
lRtopMean 0.611295
lRtopStd 0.184714
lRtopStdnorm 0.302169
lRtopMedian 0.60274
lRtopQuartdelta 0.253621
lRtopQuartdeltanorm 0.420781
lRtopKurt 2.13625
lRtopTrenddiff -0.0813462
lRbotMean 1.45125
lRbotStd 0.572936
lRbotStdnorm 0.394787
lRbotMedian 1.36957
lRbotQuartdelta 0.807483
lRbotQuartdeltanorm 0.589591
lRbotKurt 2.60232
lRbotTrenddiff -0.0482516
lRrightMean 0.812441
lRrightStd 0.0918446
lRrightStdnorm 0.113048
lRrightMedian 0.80402
lRrightQuartdelta 0.142655
lRrightQuartdeltanorm 0.177427
lRrightKurt 3.61224
lRrightTrenddiff -0.00736094
lRleftMean 0.575039
lRleftStd 0.174847
lRleftStdnorm 0.304061
lRleftMedian 0.582734
lRleftQuartdelta 0.286718
lRleftQuartdeltanorm 0.492022
lRleftKurt 2.05718
lRleftTrenddiff 0.0341253

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.947368
sumTouchScores 18
meanMovementTime 1.01333
numTouches 19
undershootPercentage 0
overshootPercentage 5.26316

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.909091
sumTouchScores 10
meanMovementTime 1.6235
numTouches 11
undershootPercentage 9.09091
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 27.12
timePerZigzagCoV 0.256605
timePerZigzagSlope 0.079941
meanError 2.57543
tremorFreq 6.44531
tremorRelPower 40.4668
tremorGyroAmpMean 0.0427553
tremorGyroAmpSlope -0.00513018
tremorGyroAmpCoV 0.512853
tremorCoordAmpMean 0.123314
tremorCoordAmpSlope -0.0048288
tremorCoordAmpCoV 0.818622
tremorAccAmpMean 0.0729019
tremorAccAmpSlope -0.00480295
tremorAccAmpCoV 0.367413
tremorPcRelVar 0.771321
tremorPcX -0.169178
tremorPcY -0.985586

ZigZag Segment 1

Duration 23.88 s, Accuracy Estimate 2.948 (lower is better)

ZigZag Segment 2

Duration 17.36 s, Accuracy Estimate 2.575 (lower is better)

ZigZag Segment 3

Duration 34.52 s, Accuracy Estimate 2.71 (lower is better)

ZigZag Segment 4

Duration 32.88 s, Accuracy Estimate 2.338 (lower is better)

ZigZag Segment 5

Duration 26.96 s, Accuracy Estimate 2.307 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 13.68
timePerZigzagCoV 0.223421
timePerZigzagSlope -0.131871
zigzagHeightMean 46.8519
zigzagHeightCoV 0.0689234
zigzagHeightSlope -0.0336133
meanError 0.0524964
tremorFreq 6.44531
tremorRelPower 23.5393
tremorGyroAmpMean 0.041632
tremorGyroAmpSlope 0.0087638
tremorGyroAmpCoV 0.332443
tremorCoordAmpMean 0.172693
tremorCoordAmpSlope 0.00595223
tremorCoordAmpCoV 0.79628
tremorAccAmpMean 0.0802244
tremorAccAmpSlope 0.00587697
tremorAccAmpCoV 0.436258
tremorPcRelVar 0.817615
tremorPcX 0.0776146
tremorPcY 0.996983

ZigZag Offset Segment 1

Duration 17.4 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 2

Duration 16.56 s, Accuracy Estimate 0.071 (lower is better)

ZigZag Offset Segment 3

Duration 11.92 s, Accuracy Estimate 0.059 (lower is better)

ZigZag Offset Segment 4

Duration 11.72 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 5

Duration 10.8 s, Accuracy Estimate 0.051 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.54}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.63}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.8657488568959848}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9435283793798832}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.7656774390303933}